CRF is sometimes referred to as a 'misery neurotransmitter' because it is thought to cause the anxiousness felt by addicts until they receive temporary relief by drinking again or taking drugs.

CRF有时又被称为“痛苦神经传递素”，因为它被认为是上瘾者所感受到的焦虑感的诱因，这些感觉直到上瘾者再次饮酒或吸毒时才会暂时缓解。