In his view, ageing is about the accumulation of damage, and is not under tight genetic control. Sirtuins will, he says, probably be but a small part of a more complicated picture.

Rattan博士认为老化是损伤的不断积累，而且老化并未从基因上得到严格的控制。他说，去乙酰化酶也许只是更纷繁复杂的情形中很小的一部分。