The RUPP network conducted two major trials. In the first trial children with autism accompanied by tantrums, aggression and self-injury were treated with the antipsychotic risperidone (Risperdal).

RUPP网络进行了两个主要的试验，第一个试验中对伴有大发脾气，攻击和自我伤害的行为的自闭症儿童以抗精神病药risperidone来治疗。