The hard nodes in the inoculated positions of the skin and the swollen spleens with enlargement of reticular endothelial cells were found in the mice immunized with large dose of WCV.

用大剂量WCV免疫小鼠，在接种部位出现皮下结节，小鼠的脾脏明显肿大，组织病理学检查脾脏有不同程度的网状内皮细胞增生。