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来源：雅诚德英语网
It was related to the dosage and time. Along with the time extension and the cuprizone dosage increasement, the cell apoptosis increased and the demyelination aggravated.
结论环己酮草酰二腙可诱导大鼠脑白质脱髓鞘、空泡样变，呈时间剂量相关性，随着时间延长和累积剂量增加，细胞凋亡及空泡形成增多；