The main reason responsble to leukoaraiosis was ischemia in white matter leading to neuroglia degeneration and demyelination. Leukoaraiosis may cause or deteriorate disturbance of intelligence.

白质小动脉缺血导致神经胶质细胞变性和白质纤维髓鞘脱失是发生白质疏松的主要原因，它可能导致或加重智能障碍。