All of these issues are rooted in the fact that no one nation can meet the challenges of the 21st century on its own, nor effectively advance its interests in isolation.

上述所有问题都基于这样一个事实：没有任何一个国家能够单独应对21世纪的挑战，也没有任何一个国家能在闭关自守的情况下有效地增进自身利益。