Wilson doesn't acknowledge this because his view of relationship between history and literature is only that history influences literature, not that the influence can be reciprocal.
In spite of the fact that de-icing fluid had been applied at the gate, a departure delay after the aircraft taxied on to the runway allowed ice to re-form on the wings, leading to the crash.
According to Nina Baym, who has termed this genre "woman's fiction", the massive popularity of these novels claimed a place for women in the writing profession.
But that may not be a good gauge of how large populations of sick patients will tolerate or respond to a variant of the medication they've already been on, say critics of the approval process.