Gastrointestinal stromal tumors (GIST) is the most common mesenchymal tumors of the gastrointestinal tract. Activating mutations of KIT has been identified in the vast majority of GIST.

胃肠道间质瘤是原发于胃肠道和腹部的间叶源性肿瘤，绝大多数存在c -Kit基因突变。